Galveston civic leaders planned on building the Hotel Galvez in 1898 after a fire destroyed another large hotel (the Beach Hotel) on Galveston Island. After the Hurricane of 1900, the plans accelerated in order to draw tourists back to the island. The hotel was designed by Mauran, Russell & Crowell of St. Louis, Missouri using a combination of Mission Revival and Spanish Revival styles. The hotel opened in June 1911 at a cost of $1 million.
The building was added to the National Register of Historic Places on April 4, 1979.
Hotel Galvez & Spa, A Wyndham Grand Hotel is a member of Historic Hotels of America, the official program of the National Trust for Historic Preservation.