West Texas is Big Bend. Sandwiched between Mexico and New Mexico, the area integrates Hispanic culture into the American mix. The Pecos and the Rio Grande rivers are just two of the natural attractions in this part of the state, the latter forming a natural border between Texas and Mexico. In Big Bend National Park, one of the largest national parks in the United States, guests can hike, float on commercial float trips on the Rio Grande, camp and birdwatch.

The largest center in the region is El Paso, a city with easy access to its sister city of Juarez, Mexico. Attractions in El Paso include Fort Bliss, the Ysleta, Socorro and San Elizario missions, and the El Paso Museum of Art. Other areas of interest in this region include the Amistad National Recreation Area, Guadalupe Mountains National Park and the city of Del Rio.